Experiments on mazindol and food intake in the rat.

by Kevin Francis Sweeney

Written in English
Published: Downloads: 258
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Thesis (Ph. D.)--The Queen"s University of Belfast, 1983.

  a, Food intake, body weight and activity of 6 mice were examined for 24 days before and after QIH. The first and second dashed vertical lines denote intraperitoneal injection of saline and CNO. On the day of each experiment, food was removed from the rat's cage, and the in vitro recovery of concentric microdialysis probes [ mm diameter × mm cuprophan (Akzo Nobel Fraser, Wuppertal, Germany) membrane] was determined before probes were placed into the VMN, LHA, or PVN. Probe efficiencies were –%. "An intake of g protein/kg diet is regarded as the minimum amount for growing rats, and results in some degree of malnutrition, particularly when under stress such as pregnancy. I’m doing a master class at the 92nd St Y’s series.. Join me for a conversation about my new book, Let’s Ask Marion: What You Need to Know About the Politics of Food, Nutrition, and Health.. I will talk about the politics of food in the Covid era. – p.m.

The hedonic impact and intake of food are increased by midazolam microinjection in the parabrachial nucleus. Brain Research, , , Söderpalm, A. H. V., & K. C Berridge. Food intake after diazepam, morphine, or muscimol: microinjections in the . Even without stating the same thing about the U.S. diet, some physicians suggest that patients with these problems cut back on the volume of food intake, get more exercise, avoid high cholesterol-containing foods, reduce salt intake, and eat more fiber. The book authors go much further and suggest several approaches to not only improve the U.S.   Overnight treatment with these drugs suppressed food intake in a dose-dependent manner despite different anorexic mechanisms of action for each of the drugs. In addition, the drugs had no effect on morbidity or motility during the experiments. Figure 4 shows the distance of spontaneous swimming. But skip back in time to , when Frederick Gowland Hopkins (born J ), then a research fellow in biochemistry at Trinity College, University of Cambridge, published in the Journal of Physiology a paper titled “Feeding Experiments Illustrating the Importance of Accessory Food Factors in Normal Dietaries.” In his investigations exploring the relationship .

  In a separate experiment, vascular reactivity was measured after acute exposure to ∼10 mM fructose in isolated aortic rings from untreated rats. Results: Although high-fructose intake statistically significantly increased blood pressure and body weight, it did not affect contraction and relaxation in aortic rings.   The blog "10 Scientific Studies Proving GMOs Can Be Harmful To Human Health" is now a fixture on cyberspace. A scientist takes a hard look at the claims and finds the "studies" tell a different. As one reader recently commented on a different blog, I lit a fire to the China Study five years ago but Denise Minger just burned the whole thing down.. Lighting the Fire In the spring of , I wrote a review of Dr. T. Colin Campbell’s The China Study for the Weston A. Price Foundation’s journal Wise Traditions.. The mostly unchanged version of this review on Cholesterol-And . Abbreviations: OB, outbred; IB, inbred; HB, hybrid. SOURCE: Adapted from Poiley (). logical appearance of tissue lesions, and nucleic acid or protein content of tissue. The requirement for any nutrient may vary with the criteria used. Traditionally, rapid growth leading to .

Experiments on mazindol and food intake in the rat. by Kevin Francis Sweeney Download PDF EPUB FB2

1. The effects of orally- and intravenously-administered d-amphetamine-SO 4, fenfluramine-HCl HCl and cocaine-HCl on food intake in the fasted rat were compared. During the first hour after presentation of food to the animals, ED 50 values for suppression of food intake after intravenous injection were: d-amphetamine-SO 4, mg/kg; fenfluramine Cited by: 7.

Mazindol is a tricyclic anorexigenic agent that is unrelated to and less toxic than [amphetamine], but with some similar side inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.

Mazindol is only approved in the United States for the treatment of Duchenne muscular dystrophy, and is not marketed or available in the United. They developed a consistent food intake habit within 1 week. On the day of the experiment, they received d-amphetamine sulphate ( mg/ kg), mazindol { mg/kg) or an equal volume of saline i.p.

These dose of d-amphetamine and mazindol were chosen after preliminary trials to obtain a comparable substantial reduction of food by: Since the tail of the rat is a major thermoregula- tory organ with a large surface available for heat loss, an enhanced blood flow in the dilated veins and hence a successful venipuncture can be ensured y warming prior to injection.

Warming the whole rat to a temperature around C by placing the animal into a thermostatically warmed 'hot-box'. The insight into human addiction that grows from the Rat Park research is not terribly complicated, but it took me about 15 years to grasp it clearly and another 10 years to assemble the evidence from human history and anthropology to show that it is true and another 5 years to write a book about it.

Abstract. Serotonin (5HT) injected into the rat paraventricular nucleus (PVN) of the hypothalamus reduces food intake and antagonizes the hyperphagia induced by noradrenaline administered in the same area (1).

Ivan Pavlov studied the reflexive flow of saliva in dogs. He used meat powder or other food to trigger the salivation. It was later observed that the salivation in the dog was triggered even before the food was placed in its mouth. In this experiment, _____ was the unconditioned stimulus.

Swiss mice received a single acute administration of mazindol (, and mg/kg, ip) or saline. After 2 h, the animals were killed by decapitation; the brain was removed and used for the evaluation of activities of mitochondrial respiratory chain complexes, Krebs cycle enzymes and creatine kinase.

Water consumption is strongly linked to food intake and declines dramatically in fasted or food-restricted animals. Typical h food intake for a 7–9 week old male mouse fed standard chow is 10–12 Kcal/g body weight (mean across 13 strains; Jackson Laboratory, Mouse Phenome Database) with approximately 70% consumed during the dark.

The laboratory rat (Rattus norvegicus) has long been favored as an experimental model for nutritional research because of its moderate size, profligate reproduction, adaptability to diverse diets, and tractable nature.

It is now the species of choice for many experimental objectives because of the large body of available data and the development of strains with specific.

In this experiment you will investigate which pets eat more than other pets by comparing the food intake of different species of pets. Food intake is how much food your pet eats, and can be measured by weighing the dry weight of your pet's food in.

The rats on the 5% casein diet ate much less food than the rats on the 20% casein diet. Expecting this, Campbell and his student divided the rats into three groups rather than two.

They fed the third group 20% casein but restricted their total food intake to the measly amount of food the 5% casein group was eating spontaneously. Dakin CL, Gunn I, Small CJ, Edwards CM, Hay DL, et al.

() Oxyntomodulin inhibits food intake in the rat. Endocrinology – View Article Google Scholar 9. Konturek SJ, Konturek JW, Pawlik T, Brzozowski T () Brain-gut axis and its role in the control of food intake.

Steven J. Cooper's research works with 4, citations and 2, reads, including: From Claude Bernard to Walter Cannon. Emergence of the concept of homeostasis.

A number of peptides also affect food intake. The noradrenergic drugs phentermine, diethylpropion, mazindol, benzphetamine, and phendimetrazine. There were no differences in food intake over the middle third of the experiment (P =F = ) or final third of the experiment (P =F = ).

Pairwise comparisons of LD and SD groups identified significant differences in food intake only in the first third of the experiment (Fig. A new systematic review published in the International Journal of Obesity looks at the totality of evidence investigating whether consuming low energy sweeteners (LES), such as aspartame, sucralose, or stevia, is a net benefit or detriment for weight control.

In addition to providing some clarity on the answer, the review also provides some insight into how different kinds of. Cooper S. () Neuropeptides and Food and Water Intake, in Psychopharmacology and Food, (Sandler M.

and Silverstone T., eds.), Oxford University, Oxford, UK. Google Scholar Cooper S. and Dourish C. () Hypodipsia, stereotypy and hyperactivity induced by ß-phenylethylamine in the water-deprived rat. each fluid. This loss (usually less than 10% of total intake) was subtracted proportionately to each rat's intake for the day.

Other environmental variables were controlled by situat- ing both housing environments in the same large room, with a 12 hr light-dark cycle. Food was available ad lib through- out.

In an experiment, quail and rats were given blue, sour water to drink, after which the animals were made sick. when food intake increases, activity increases. c) both a and b are correct d) neither a nor b are correct inserted a stimulus rat into the chamber just prior to the delivery of food, the other rat a) displayed schedule-induced.

Restriction of the caloric intake alone gave similar results. Restriction of food intake was effective in experiments in which extra vitamin B 1 was given in the diet and also when a diluted saline solution was given by stomach tube to assure a sufficient intake of fluid.

In their experiments, Hoebel and colleagues in his lab started rats on a pattern of bingeing by withholding food for 12 hours when the rats were sleeping and.

The effects of 2-MG on food intake and diarrhea were evaluated and compared with the long-chain fatty acid (LCFA) in rats by intrajejunal infusion. 2-MG did not induce diarrhea under the condition in which it comparably reduced food intake as compared with LCFA, suggesting that 2-MG stimulates satiety without inducing diarrhea, different from.

Ghrelin is a newly discovered peptide that is released from the stomach and from neurons in the hypothalamic arcuate nucleus (ARC) and potently stimulates growth hormone release and food intake. Neuropeptide-Y (NPY) neurons in the ARC play an important role in the stimulation of food intake.

The present study aimed to determine whether ghrelin directly activates NPY. Ghrelin stimulates, while glucagon-like peptide-1 (GLP-1) and peptide YY() [PYY()] inhibit, food intake and gastric emptying in rats. We determined the dose-dependent effects of a 3-h intravenous infusion of ghrelin at dark onset on food intake in freely feeding rats, and on the inhibitory effects of intravenous infusion of GLP-1 and PYY() on food intake and gastric.

The neuronal uptake of norepinephrine (NE) in sympathetically innervated tissues is mediated by a high-affinity NE uptake transporter (NET). Rat interscapular brown adipose tissue (ISBAT) is.

The rat found early use in laboratory research in five areas: W. Small suggested that the rate of learning could be measured by rats in a maze; a suggestion employed by John B. Watson for his Ph.D. dissertation in The first rat colony in America used for nutrition research was started in January by Elmer McCollum and then, nutritive requirements of rats were used by.

Function – to transport food from the pharynx to the stomach by gravity and by. peristalsis. Peristalsis – primary = a continuation of the peristaltic wave from pharynx - secondary waves result from distention of the oesophagus by the retained food.

Speed 4 cm/s. The swallowing time – for a compact food s a fluid s. The food is not particularly exotic: Mediterranean-style combinations of fish with Greek-style potatoes, for instance, or sweet-and-sour chicken with rice.

Whether the meals are bad or good is. The capacity to adjust food intake in response to changing energy requirements is essential for survival. Recent progress has provided. The Pusztai affair is a controversy that began in Protein scientist Árpád Pusztai went public with the initial results of unpublished research he was conducting at the Rowett Institute in Aberdeen, Scotland, investigating the possible effects of genetically modified potatoes upon rats.

Pusztai claimed that the genetically modified potatoes had stunted growth and repressed the. Rat chow plus crackers, cookies, and chocolate all at the same time. Adding a palatable food to the cage (crackers, cookies, or chocolate) increased food intake, as expected.

Adding multiple palatable foods at once increased food intake further, suggesting that variety in addition to palatability contributed to food intake. This was a groundbreaking experiment and officially established the food–gene connection; it also helped mark the birth of epigenetics.

The Road to Recovery: An Integrative Mind-Body Approach By harnessing the power of epigenetics, it is possible to rein in impulsivity, strengthen PFC function and recover from food addiction for a lifetime.